Uses:

Nexala® by Laboratorios Farmolab is a food supplement for the general population and particularly for people with joint disorders.

Security:

Unlike other alternatives that are commonly offered for joint problems, Nexala® 30 capsules can be used for long periods without gastric complications.

The ingredients safety has been verified in different clinical studies. In this sense, there are studies that describe the mechanisms of action of ingredients such as Theracurmin®, Akbamax® and Vitamin D. (see bibliographic references section).

Presentation:

NATIONAL CODE (C.N.): 192885.6
Box of 30 capsules.

Instructions for use:

It is recommended to take 1-2 capsules per day

A minimum of 6 months is recommended. Nexala® can be taken on an ongoing long-term basis.

It is suitable for diabetics and celiacs.

Store in a cool and dry place, away from light, at a temperature less than 25° C. Avoid sudden changes in temperature. The expiration date is applicable to the product with the original packaging intact and properly stored. Keep out of reach of children under 3 years of age. Food supplements are not intended to replace a varied and balanced diet and a healthy lifestyle. Do not exceed the suggested daily dose. Do not take in case of hypersensitivity to one or more components of this product.

THERACURMIN® – 90mg

Is a Submicron Colloidal  Dispersion Particles of Curcuminoids and Curcuminoids that are stable and dispersible in water; this new and unique preparation method is characterised by a very high level of absorbency and bioavailability. Theracurmin® is a molecule that has an important clinical development, its efficacy and safety are suported in different clinical trials, it has numerous investigations and clinical trial published in differernt areas, such as the osteoarticular area, where it has numerous publications, all of them available through publications in scientific journals and available for consuyltation in media such as pubmed and others. (see bibliographic references section).

AKBAMAX® – 100mg

This is has numerous clinical evidences obtained through different clinical studies in which it has been possible to demonstrate its calming and anti-inflammatory action, and its benefits in the improvement of joint symptoms.a specific preparation from boswellia serrata, in which we left the effective chemical active substances, in particular acetyl-11-keto-beta-boswellic acid (AKBA), which we have enriched over 5 times; and we have eliminated the beta–boswellic, which is the least beneficial and the main component in other extracts. has numerous clinical evidences obtained through different clinical studies in which it has been possible to demonstrate its calming and anti-inflammatory action, and its benefits in the improvement of joint symptoms. (see bibliographic references section).

VITAMIN D – 10μg

Essential for the health of the bone structure. Helps build and maintain strong bones. Plays an important role in achieving the right bone density and supports calcium absorption into the bones. (see bibliographic references section).

Benito-Ruiz P. Guías y recomendaciones para el diagnóstico y tratamiento de la artrosis: en busca del consenso. Semin Fund Esp Reumatol. 2012;13(Supl 1):3-8. Bruyère O, Cooper C, Pelletier JP, Branco P, Luisa Brandi P, Guillemin F, et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 2014;44(3):253-63. Giménez S (coord.), Möller I (coord.), Casals JL, Martínez F. Guías clínicas Semergen. Artrosis. Badalona (Barcelona): SEMERGEN Ediciones;2011. Giménez S (coord.). SEMERGEN. DOC. Patología osteoarticular. 2.a ed. Madrid: Edicomplet, 2009. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Kizhakkedath R. et al. Molecular Medicine Reports 8: 1542-1548, 2013. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clinical Kuptniratsaikul et al. Interventions in Aging 2014:9 451–458. Ability of Curcuminoid Compared to Diclofenac Sodium in Reducing the Secretion of Cycloxygenase-2 Enzyme by Synovial Fluid’s Monocytes of Patients with Osteoarthritis. Kertia et al. Acta Med Indones-Indones J Intern Med. 2012. Chandran B, Goel A. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytother Res. March 9, 2012 doi: 10.1002/ptr.4639. Poecke D, Tausch L, Altmann K, et al .Induction of central signalling pathways and select functional effects in human human platelets by beta-boswellic acid, Br. J. Pharmacol .,2005 ,146. Sharma ML, Bani S, Singh GB. Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int J Immunopharmacol 1989;11:647-652. Palmoski MJ, Brandt KD. Effect of  salicylate on proteoglycan metabolism in normal canine articular cartilage in vitro. Arthritis Rheum 1979;22:746-754. Dekel S, Falconer J, Francis MJ. The effect of antiinflammatory drugs on glycosaminoglycan sulphation in pig cartilage. Prostaglandins Med 1980;4:133-140. Reddy GK, Chandrakasan G, Dhar SC. Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents. Biochem Pharmacol 1989;38:3527-3534. Henrotin Y, Clutterbuck AL, Allaway D, et al. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010;18(2):141-9. Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency -A Double-Blind, 3-Way Crossover Study-Sunagawa Y et al J Nutr Sci Vitaminol, 61, 37–44, 2015. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double -blind, placebo-controlled prospective study Nakagawa et al. J Orthop Sci (2014) 19:933–939. Highly Bioavailable Curcumin Powder Suppresses Articular Cartilage Damage in Rats With Mono-Iodoacetate (MIA)-induced Osteoarthritis. Hyun-Ji Park, Chul-Kyu Lee,, Si-Hwan Song, Jee-Hye Yun, Ahsa Lee, Hee-Jung Park. Food Sci Biotechnol 29, 251–263 (2020). The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study. Yasuaki Nakagawa, et al.  Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders Volume 13: 1–8, 2020. Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle  function in patients with knee osteoarthritis. Yun-A Shin, Min-Hwa Suk, Hee-Seung Jang, Hye-Jung Choi. Journal of Exercise Rehabilitation 2017;13(6):684-692. Eficacia a Corto Plazo de Nexala® en el Tratamiento de Pacientes con Gonartrosis y Coxartrosis. Martínez P., Zurita N., Lledó J., Unidad de Traumatología Mittelmeer Klinik. Evidencias Científicas. ©Farmolab Internal data 2019. Experiencia Clínica con Nexala® en pacientes con artrosis de manos con componente inflamatorio y mala respuesta a otros tratamientos. Evidencias Científicas. ©Farmolab Internal data 2020. Experiencia Clínica con Nexala® en pacientes con Artritis Reumatoide con limitaciones en su tratamiento habitual. Evidencias Científicas. ©Farmolab Internal data 2020.