[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.4.5″][et_pb_fullwidth_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2020\/05\/nexala.jpg” alt=”Nexala” title_text=”Nexala” _builder_version=”4.4.5″][\/et_pb_fullwidth_image][et_pb_fullwidth_code _builder_version=”4.9.4″ custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” background_last_edited=”on|phone”][\/et_pb_fullwidth_code][et_pb_fullwidth_code _builder_version=”4.9.4″ custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” background_last_edited=”on|phone”][\/et_pb_fullwidth_code][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.4.5″ use_background_color_gradient=”on” background_color_gradient_start=”#991a19″ background_color_gradient_end=”#fff” background_color_gradient_direction=”90deg” custom_margin=”40px||0px||false|false” custom_padding=”0px||0px||false|false”][et_pb_row _builder_version=”4.4.5″ custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false”][et_pb_column type=”4_4″ _builder_version=”4.4.5″][et_pb_cta title=”Nexala\u00ae” _builder_version=”4.9.4″ header_font=”|||on|||||” header_font_size=”52px” body_font_size=”13px” background_color=”rgba(0,0,0,0)” text_orientation=”left” custom_margin=”||||false|false” custom_padding=”20px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”right” header_font_size_tablet=”” header_font_size_phone=”32px” header_font_size_last_edited=”on|phone”][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.4.5″][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.4.5″ min_height=”945.5px” custom_margin=”|auto|-430px|auto||”][et_pb_column type=”3_5″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” animation_style=”slide” animation_direction=”bottom” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” header_font_tablet=”” header_font_phone=”” header_font_last_edited=”on|desktop” header_font_size_tablet=”” header_font_size_phone=”18px” header_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone”]<\/p>\n

Nexala\u00ae 30 Capsules used for:<\/h3>\n

People with joint problems related to age, proffessional activity or sports.<\/p>\n

<\/h3>\n

<\/h3>\n

Nexala\u00ae 30 Capsules:<\/h3>\n

Oxidative stress is defined as an excess in the formation or an insufficient removal of highly reactive molecules that can cause oxidative damage. Curcumin, can help control oxidative stress<\/strong>.\u00a0The bioactive turmeric extract (Theracurmin\u00ae), included in Nexala\u00ae, is obtained through a specific formulation process, which improves its bioavailability to obtain its maximum benefits.<\/p>\n

From boswellia serrata resine, its active components are extracted, \u201cboswellic acids\u201d, may have a beneficial role in improving bone, muscle and joint stress\u00a0and in maintaining good joint health<\/strong>. The most important is boswellic acid – AKBA, a component of Nexala\u00ae which we have been enriched more than 5 times through a specific formulation (Akbamax\u00ae).<\/p>\n

Vitamin D helps us to maintenance of bones in normal conditions and to maintain normal levels of calcium in the blood<\/strong>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2020\/05\/nexala-caja.jpg” alt=”Nexala” title_text=”nexala-caja” force_fullwidth=”on” _builder_version=”4.4.5″ animation_style=”slide” animation_direction=”right”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.4.5″ use_background_color_gradient=”on” background_color_gradient_start=”#991a19″ background_color_gradient_end=”#ffffff” background_color_gradient_direction=”90deg” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” collapsed=”on”][et_pb_row _builder_version=”4.4.5″ custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false”][et_pb_column type=”4_4″ _builder_version=”4.4.5″][et_pb_cta title=”INFORMATION” _builder_version=”4.9.4″ header_font=”|||on|||||” header_font_size=”52px” body_font_size=”13px” background_color=”rgba(0,0,0,0)” text_orientation=”left” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” custom_margin=”||||false|false” custom_padding=”20px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”right” header_font_size_tablet=”” header_font_size_phone=”32px” header_font_size_last_edited=”on|phone”][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.4.5″ collapsed=”on”][et_pb_row _builder_version=”4.4.5″ custom_margin=”||||false|false” custom_padding=”||||false|false”][et_pb_column type=”4_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ animation_style=”slide” animation_direction=”bottom” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” header_3_font_size_tablet=”” header_3_font_size_phone=”20px” header_3_font_size_last_edited=”on|desktop”]<\/p>\n

Uses:<\/h3>\n

Nexala\u00ae by Laboratorios Farmolab is a food supplement for the general population and particularly for people with joint disorders.<\/p>\n

Security:<\/h3>\n

Unlike other alternatives that are commonly offered for joint problems, Nexala\u00ae 30 capsules can be used for long periods without gastric complications.<\/p>\n

The ingredients safety has been verified in different clinical studies. In this sense, there are studies that describe the mechanisms of action of ingredients such as Theracurmin\u00ae, Akbamax\u00ae and Vitamin D. (see bibliographic references section<\/em>).<\/p>\n

Presentation:<\/h3>\n

NATIONAL CODE (C.N.): 192885.6
Box of 30 capsules.<\/p>\n

Instructions for use:<\/h3>\n

It is recommended to take 1-2 capsules per day<\/p>\n

A minimum of 6 months is recommended. Nexala\u00ae can be taken on an ongoing long-term basis.<\/p>\n

It is suitable for diabetics and celiacs.<\/p>\n

Store in a cool and dry place, away from light, at a temperature less than 25\u00b0 C. Avoid sudden changes in temperature. The expiration date is applicable to the product with the original packaging intact and properly stored. Keep out of reach of children under 3 years of age. Food supplements are not intended to replace a varied and balanced diet and a healthy lifestyle. Do not exceed the suggested daily dose. Do not take in case of hypersensitivity to one or more components of this product.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.4.5″ use_background_color_gradient=”on” background_color_gradient_start=”#991a19″ background_color_gradient_end=”#ffffff” background_color_gradient_direction=”90deg” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” collapsed=”on”][et_pb_row _builder_version=”4.4.5″ custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false”][et_pb_column type=”4_4″ _builder_version=”4.4.5″][et_pb_cta title=”Composition” _builder_version=”4.9.4″ header_font=”|||on|||||” header_font_size=”52px” body_font_size=”13px” background_color=”rgba(0,0,0,0)” text_orientation=”left” custom_margin=”||||false|false” custom_padding=”20px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”right” header_font_size_tablet=”” header_font_size_phone=”32px” header_font_size_last_edited=”on|phone”][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ collapsed=”off”][et_pb_row _builder_version=”4.4.5″ custom_margin=”||||false|false” custom_padding=”||||false|false”][et_pb_column type=”4_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ animation_style=”slide” animation_direction=”bottom” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”20px” header_3_font_size_last_edited=”on|desktop”]<\/p>\n

THERACURMIN\u00ae – 90mg<\/h3>\n

Is a Submicron Colloidal\u00a0 Dispersion Particles of Curcuminoids and Curcuminoids that are stable and dispersible in water; this new and unique preparation method is characterised by a very high level of absorbency and bioavailability. Theracurmin\u00ae is a molecule that has an important clinical development, its efficacy and safety are suported in different clinical trials, it has numerous investigations and clinical trial published in differernt areas, such as the osteoarticular area, where it has numerous publications, all of them available through publications in scientific journals and available for consuyltation in media such as pubmed and others. (see bibliographic references section<\/em>).<\/p>\n

AKBAMAX\u00ae – 100mg<\/h3>\n

This is has numerous clinical evidences obtained through different clinical studies in which it has been possible to demonstrate its calming and anti-inflammatory action, and its benefits in the improvement of joint symptoms.a specific preparation from boswellia serrata, in which we left the effective chemical active substances, in particular acetyl-11-keto-beta-boswellic acid (AKBA), which we have enriched over 5 times; and we have eliminated the beta\u2013boswellic, which is the least beneficial and the main component in other extracts. has numerous clinical evidences obtained through different clinical studies in which it has been possible to demonstrate its calming and anti-inflammatory action, and its benefits in the improvement of joint symptoms. (see bibliographic references section<\/em>).<\/p>\n

VITAMIN D – 10\u03bcg<\/h3>\n

Essential for the health of the bone structure. Helps build and maintain strong bones. Plays an important role in achieving the right bone density and supports calcium absorption into the bones.\u00a0(see bibliographic references section<\/em>).<\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI0NyJ9fQ==@” button_text=”Back” _builder_version=”4.4.5″ _dynamic_attributes=”button_url” custom_button=”on” button_text_color=”#9a1a18″ button_border_width=”1px” button_border_radius=”10px” button_icon=”%%19%%” button_icon_placement=”left” custom_padding=”|30px||30px|false|false”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ use_background_color_gradient=”on” background_color_gradient_start=”#991a19″ background_color_gradient_end=”#ffffff” background_color_gradient_direction=”90deg” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” collapsed=”on” disabled_on=”on|on|on” disabled=”on”][et_pb_row _builder_version=”4.4.5″ custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false”][et_pb_column type=”4_4″ _builder_version=”4.4.5″][et_pb_cta title=”ScIENTIFIC EVIDENCE ” _builder_version=”4.9.4″ header_font=”|||on|||||” header_font_size=”52px” body_font_size=”13px” background_color=”rgba(0,0,0,0)” text_orientation=”left” custom_margin=”||||false|false” custom_padding=”20px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”right” header_font_size_tablet=”” header_font_size_phone=”32px” header_font_size_last_edited=”on|desktop”][\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ max_width=”100%” min_height=”389.6px” custom_margin=”9px||-198px||false|false” custom_padding=”0px||||false|false” animation_style=”fade” animation_delay=”600ms” hover_enabled=”0″ collapsed=”off” disabled_on=”on|on|on” disabled=”on” sticky_enabled=”0″][et_pb_row column_structure=”1_4,3_4″ disabled_on=”off|off|off” _builder_version=”4.9.4″ min_height=”218.6px” custom_margin=”|auto|-55px|auto|false|false” custom_padding=”2px||0px||false|false”][et_pb_column type=”1_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”33px” header_font_size=”25px” header_3_font_size=”35px” custom_margin=”||21px|0px|false|false” custom_padding=”33px||2px|0px|false|false” header_3_font_size_tablet=”” header_3_font_size_phone=”35px” header_3_font_size_last_edited=”on|phone”]<\/p>\n

April<\/h3>\n

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2021<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2021\/04\/Recurso-16.png” title_text=”Recurso 16″ url=”http:\/\/www.pieronline.jp\/content\/article\/0386-3603\/49020\/229″ url_new_window=”on” _builder_version=”4.9.4″ _module_preset=”default” width=”100%” custom_padding=”|||0px||” hover_enabled=”0″ sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|on|on” _builder_version=”4.9.4″ _module_preset=”default” custom_padding=”3px||2px|||”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_column type=”1_4″ _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.9.4″ _module_preset=”default” min_height=”23px” custom_margin=”0px||||false|false” custom_margin_tablet=”” custom_margin_phone=”100px||||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||false|false” hover_enabled=”0″ background_last_edited=”on|phone” disabled=”on” sticky_enabled=”0″][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” min_height=”20px” custom_padding=”2px||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” min_height=”36px”]<\/p>\n

P-ISSN: 0386-3603<\/strong><\/p>\n

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ABSTRACT<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.9.4″ _module_preset=”default” min_height=”361px” custom_margin=”||-3px|||” custom_padding=”5px||50px|||” animation_style=”fade” hover_enabled=”0″ disabled=”on” sticky_enabled=”0″][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” min_height=”219px” custom_padding=”4px||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font=”||||||||” min_height=”296px” custom_padding=”0px||0px||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop”]<\/p>\n

Objectives: <\/strong>Evaluate the short-term safety and effectiveness of Nexala\u00ae in patients with gonarthrosis and coxarthrosis; Nexala\u00ae, a formulation containing Theracurmin\u00ae\uff08highly bioavailable curcumin), Akbamax\u00ae\uff08enriched boswellic acid extract\uff09and Vitamin D3\uff08Cholecalciferol).<\/p>\n

Methods:<\/strong> 30 patients were selected, 20 were recruited and all 20 completed the study. Treatment with Nexala\u00ae was well tolerated and did not produce any adverse effects.<\/p>\n

Results:<\/strong> The formulation of Nexala\u00ae\uff082 capsules x day\uff09reduced pain, stiffness and improved functionality significantly\uff08P\uff1c0.0001\uff09after a 28 day period of continuous treatment measured by WOMAC and the Lequesne Index.<\/p>\n

Conclusions:<\/strong> Nexala\u00ae shows great potential for the treatment of patients with arthrosis; its short term effectiveness as well as its tolerability profile makes it an ideal candidate when we need to decrease pain and inflammation and improve functionality in patients with gonarthrosis and coxarthrosis.<\/p>\n

Authors: <\/strong>Mart\u00ednez Pablo1, Zurita Nestor2, Lled\u00f3 Jorge1. (1.Mittelmeer KLINIK Trauma Unit, Spain, 2.IMED Hospital Trauma Unit. Spain).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ min_height=”432.6px” custom_margin=”||-63px|||” custom_padding=”50px|||||” animation_style=”fade” animation_delay=”600ms” hover_enabled=”0″ collapsed=”off” disabled_on=”on|on|on” disabled=”on” sticky_enabled=”0″][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.9.4″ min_height=”218.6px” custom_margin=”|auto|-55px|auto|false|false” custom_padding=”2px||0px||false|false”][et_pb_column type=”1_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”33px” header_3_font_size=”35px” custom_margin=”|||0px|false|false” custom_padding=”33px||2px|0px|false|false”]<\/p>\n

November<\/h3>\n

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2014<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2021\/04\/Recurso-18.png” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/25308211\/” url_new_window=”on” _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” min_height=”32px” custom_margin=”0px||-13px||false|false” custom_margin_tablet=”” custom_margin_phone=”-3px||-52px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”7px||0px|||”]<\/p>\n

PMID: 25308211.\u00a0\u00a0<\/strong>PMCID: PMC4244558<\/strong><\/p>\n

DOI: 10.1007\/s00776-014-0633-0<\/strong><\/span><\/p>\n

ABSTRACT<\/strong> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font=”||||||||” min_height=”296px” custom_padding=”0px||0px||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop”]<\/p>\n

Background:<\/strong> We previously developed a surface-controlled water-dispersible form of curcumin and named it Theracurmin(\u00ae) (Theracurmin; Theravalues, Tokyo, Japan). The area under the blood concentration-time curve of Theracurmin in humans was 27-fold higher than that of curcumin powder. We determined the clinical effects of orally administered Theracurmin in patients with knee osteoarthritis during 8 weeks of treatment.<\/span><\/p>\n

Methods:<\/strong> Fifty patients with knee osteoarthritis of Kellgren-Lawrence grade II or III and who were aged more than 40 years were enrolled in this randomized, double-blind, placebo-controlled, prospective clinical study. Placebo or Theracurmin containing 180 mg\/day of curcumin was administered orally every day for 8 weeks. To monitor adverse events, blood biochemistry analyses were performed before and after 8 weeks of each intervention. The patients’ knee symptoms were evaluated at 0, 2, 4, 6, and 8 weeks by the Japanese Knee Osteoarthritis Measure, the knee pain visual analog scale (VAS), the knee scoring system of the Japanese Orthopedic Association, and the need for nonsteroidal anti-inflammatory drugs.<\/span><\/p>\n

Results:<\/strong> At 8 weeks after treatment initiation, knee pain VAS scores were significantly lower in the Theracurmin group than in the placebo group, except in the patients with initial VAS scores of 0.15 or less. Theracurmin lowered the celecoxib dependence significantly more than placebo. No major side effects were observed with Theracurmin treatment.<\/span><\/p>\n

Conclusion:<\/strong> Theracurmin shows modest potential for the treatment of human knee osteoarthritis.<\/span><\/p>\n

Authors: <\/strong>Yasuaki Nakagawa \u00b7 Shogo Mukai \u00b7 Shigeru Yamada \u00b7 Masayuki Matsuoka \u00b7 Eri Tarumi \u00b7 Tadashi Hashimoto \u00b7 Chieko Tamura \u00b7 Atsushi Imaizumi \u00b7 Jun Nishihira \u00b7 Takashi Nakamura, \u00a0(Department of Orthopedic Surgery, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ min_height=”358.6px” custom_margin=”54px||-63px|||” custom_padding=”0px|||||” animation_style=”fade” animation_delay=”600ms” hover_enabled=”0″ collapsed=”off” disabled_on=”on|on|on” disabled=”on” sticky_enabled=”0″][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.9.4″ min_height=”218.6px” custom_margin=”|auto|-55px|auto|false|false” custom_padding=”2px||0px||false|false”][et_pb_column type=”1_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”33px” header_3_font_size=”35px” custom_margin=”|||0px|false|false” custom_padding=”33px||2px|0px|false|false”]<\/p>\n

August<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”46px” header_3_text_align=”center” header_3_font_size=”51px” min_height=”73px” custom_margin=”-29px|||||” custom_padding=”|0px||||”]<\/p>\n

2020<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2021\/04\/Recurso-17.png” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/32848491\/” url_new_window=”on” _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” min_height=”32px” custom_margin=”0px||-13px||false|false” custom_margin_tablet=”” custom_margin_phone=”-3px||-52px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”7px||0px|||”]<\/p>\n

PMID: 32848491.\u00a0 <\/strong>PMCID: PMC7425263<\/strong><\/p>\n

DOI: 10.1177\/1179544120948471<\/strong><\/span><\/p>\n

ABSTRACT<\/strong> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font=”||||||||” min_height=”296px” custom_padding=”0px||0px||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop”]<\/p>\n

Background:<\/strong> We previously developed a surface-controlled water-dispersible form of curcumin that we called Theracurmin\u00ae. The area under the blood concentration-time curve (AUC) of Theracurmin in humans was 27-fold higher than that of curcumin powder. Previously, we reported on the anti-inflammatory effects of Theracurmin for knee osteoarthritis.<\/p>\n

Hypothesis\/Purpose:<\/strong> We determined the clinical effects of orally administered Theracurmin in patients with knee osteoarthritis over a 6-month period.<\/p>\n

Study Design:<\/strong> Open prospective study.<\/p>\n

Methods:<\/strong> Fifty patients Kellgren-Lawrence grade II, III, or IV knee osteoarthritis who were above 40 years old were enrolled in this clinical study. Theracurmin containing 180 mg\/day of curcumin was administered orally every day for 6 months. To monitor for adverse events, blood biochemistry analyses were performed before and after 6 months of each intervention. The patients\u2019 knee symptoms were evaluated at 0, 1, 2, 3, 4, 5, and 6 months based on the Japanese Knee Osteoarthritis Measure, the knee pain visual analog scale, and the knee scoring system of the Japanese Orthopedic Association.<\/p>\n

Results:<\/strong> Five cases dropped out during the study, but no cases dropped out because of major problems. No major side effects were observed with Theracurmin treatment, including the blood biochemistry analysis results. The effective group included 34 cases (75.6%), while the not-effective group included 11 cases.<\/p>\n

Conclusion:<\/strong> This study demonstrates the safety and good efficacy of Theracurmin for various types of knee osteoarthritis. Theracurmin shows great potential for the treatment of human knee osteoarthritis.<\/p>\n

Authors: <\/strong>Yasuaki Nakagawa1 , Shogo Mukai1, Shigeru Yamada1, Satoru Murata2, Hiromitsu Yabumoto1, Takahiro Maeda1and Shota Akamatsu1, <\/strong>\u00a0(1.Department of Orthopedic Surgery, National Hospital Organization, Kyoto Medical Center, Kyoto, Japan. 2.Department of Orthopedic Surgery, Goshohigashi Clinic, Kyoto, Japan).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ min_height=”432.6px” custom_margin=”||-63px|||” custom_padding=”50px|||||” animation_style=”fade” animation_delay=”600ms” hover_enabled=”0″ collapsed=”off” disabled_on=”on|on|on” disabled=”on” sticky_enabled=”0″][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.9.4″ min_height=”218.6px” custom_margin=”|auto|-55px|auto|false|false” custom_padding=”2px||0px||false|false”][et_pb_column type=”1_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”33px” header_3_font_size=”35px” custom_margin=”|||0px|false|false” custom_padding=”33px||2px|0px|false|false”]<\/p>\n

October<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”46px” header_3_text_align=”center” header_3_font_size=”51px” min_height=”76px” custom_margin=”-31px|||||” custom_padding=”|0px||||”]<\/p>\n

2019<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2021\/04\/Recurso-19.png” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/32064134\/” url_new_window=”on” _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” min_height=”32px” custom_margin=”0px||-13px||false|false” custom_margin_tablet=”” custom_margin_phone=”-3px||-52px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”7px||0px|||”]<\/p>\n

PMID: 32064134.\u00a0 <\/strong>PMCID: PMC6992805.<\/strong><\/p>\n

DOI: 10.1007\/s10068-019-00679-5<\/strong><\/span><\/p>\n

ABSTRACT<\/strong> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font=”||||||||” min_height=”296px” custom_padding=”0px||0px||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop”]<\/p>\n

This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin\u00ae (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA).<\/p>\n

Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Celebrex), and three experimental groups treated with 500, 1300, or 2600 mg\/kg of TC for 5 weeks.<\/p>\n

MIA injection-induced OA caused 30% weight-bearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-\u03b1, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner.<\/p>\n

In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.<\/p>\n

Authors: <\/strong>Hyun-Ji Park1 , Chul-Kyu Lee1 , Si-Hwan Song1 , Jee-Hye Yun2 , Ahsa Lee2 , Hee-Jung Park3, \u00a0(1 Gyeonggi Bio Research Center, Chemon Inc., Gwanggyo-ro, Yeongtong-gu, Suwon, Gyeonggi-do 16229 Korea. 2 Handok Inc., 132 Teheran Street, Gangnam-gu, Seoul, 06235 Korea. 3 Department of Food and Nutrition, Yuhan University, 590 Gyeongin-ro, Bucheon-si, Gyeonggi-do 14780 Korea).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ min_height=”432.6px” custom_margin=”||-63px|||” custom_padding=”50px|||||” animation_style=”fade” animation_delay=”600ms” hover_enabled=”0″ collapsed=”off” disabled_on=”on|on|on” disabled=”on” sticky_enabled=”0″][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.9.4″ min_height=”218.6px” custom_margin=”|auto|-55px|auto|false|false” custom_padding=”2px||0px||false|false”][et_pb_column type=”1_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”33px” header_3_font_size=”35px” custom_margin=”|||0px|false|false” custom_padding=”33px||2px|0px|false|false”]<\/p>\n

December<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”46px” header_3_text_align=”center” header_3_font_size=”51px” min_height=”76px” custom_margin=”-29px|||||” custom_padding=”|0px||||”]<\/p>\n

2017<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2021\/04\/Recurso-20.png” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/29326901\/” url_new_window=”on” _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” min_height=”32px” custom_margin=”0px||-13px||false|false” custom_margin_tablet=”” custom_margin_phone=”-3px||-52px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”7px||0px|||”]<\/p>\n

PMID: 29326901.\u00a0 <\/strong>PMCID: PMC5747204.<\/strong><\/p>\n

DOI: 10.12965\/jer.1735064.532<\/strong><\/span><\/p>\n

ABSTRACT<\/strong> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font=”||||||||” min_height=”296px” custom_padding=”0px||0px||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone”]<\/p>\n

The purpose of this study was to investigate the short-term of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Twenty-five patients with knee osteoarthritis randomly selected to Theracurmin intake (T) group and Theracurmin in combined with exercise (T+E) group. T group (n= 13) was taken orally a capsule of 700 mg, 3 times per day, (total 2,100 mg, 35 mg\/kg-body weight). T+E group (n= 12) performed aerobic training of 30-min walking and weight training for increasing leg muscular strength.<\/p>\n

After treatment, the number of steps, muscle mass, range of motion of knee, and the muscle strength in flexion and extension significantly increased. The percent body fat, visual analogue scale, The Western Ontario and McMaster score, centers of pressure with closed eye, 10-m walking ability, stair ascending speed were significantly decreased after treatment. Although no difference observed between the T and T+E groups, the 4-week intake of Theracurmin with and without exercise appeared to be effective in reducing the pain and enhancing muscular and balancing function.<\/p>\n

Therefore, Theracurmin intake for early symptoms and additional exercise as symptoms alleviate might be an effective way of delaying and managing osteoarthritis, and additional studies investigating the effects of Theracurmin and exercise on osteoarthritis could be beneficial.<\/p>\n

Authors: <\/strong>Yun-A Shin1 , Min-Hwa Suk2 , Hee-Seung Jang1 , Hye-Jung Choi3, \u00a0(1 Department of Exercise Prescription & Rehabilitation, Dankook University, Cheonan, Korea. 2 Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Seoul, Korea. 3 Department of Counseling, Health, and Kinesiology, Texas A&M University-San Antonio, San Antonio, TX, USA).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.4″ min_height=”432.6px” custom_margin=”||-63px|||” custom_padding=”50px|||||” animation_style=”fade” animation_delay=”600ms” hover_enabled=”0″ collapsed=”off” disabled_on=”on|on|on” disabled=”on” sticky_enabled=”0″][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.9.4″ min_height=”218.6px” custom_margin=”|auto|-55px|auto|false|false” custom_padding=”2px||0px||false|false”][et_pb_column type=”1_4″ _builder_version=”4.4.5″][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”33px” header_3_font_size=”35px” custom_margin=”|||0px|false|false” custom_padding=”33px||2px|0px|false|false”]<\/p>\n

September<\/h3>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font_size=”46px” header_3_text_align=”center” header_3_font_size=”51px” min_height=”76px” custom_margin=”-30px|||||” custom_padding=”|0px||||”]<\/p>\n

2015<\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.4.5″][et_pb_image src=”https:\/\/farmolab.es\/wp-content\/uploads\/2021\/04\/Recurso-21.png” url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/25921600\/” url_new_window=”on” _builder_version=”4.9.4″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.4″ _module_preset=”default” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.4″ _module_preset=”default”][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” min_height=”32px” custom_margin=”0px||-13px||false|false” custom_margin_tablet=”” custom_margin_phone=”-3px||-52px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”7px||0px|||”]<\/p>\n

PMID: 25921600.\u00a0 <\/strong>PMCID: PMC4536282.<\/strong><\/p>\n

DOI: 10.1007\/s00421-015-3170-4<\/strong><\/span><\/p>\n

ABSTRACT<\/strong> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.4″ _module_preset=”default” text_font=”||||||||” min_height=”296px” custom_padding=”0px||0px||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone”]<\/p>\n

Purpose: <\/strong>Polyphenolic curcumin is known to have potent anti-inflammatory effects; thus the present study investigated the hypothesis that curcumin ingestion would attenuate muscle damage after eccentric exercise.<\/span><\/p>\n

Methods: <\/strong>Fourteen untrained young men (24 \u00b1 1 years) performed 50 maximal isokinetic (120\u00b0\/s) eccentric contractions of the elbow flexors of one arm on an isokinetic dynamometer and the same exercise with the other arm 4 weeks later. They took 150 mg of curcumin (theracurmin) or placebo (starch) orally before and 12 h after each eccentric exercise bout in a randomised, crossover design. Maximal voluntary contraction (MVC) torque of the elbow flexors, range of motion of the elbow joint, upper-arm circumference, muscle soreness, serum creatine kinase (CK) activity, and plasma interleukin-6 (IL-6) and tumor necrosis factor-\u03b1 (TNF-\u03b1) concentration were measured before, immediately after, and 24, 48, 72 and 96 h after each eccentric exercise. Changes in these variables over time were compared between curcumin and placebo conditions by two-way repeated measures ANOVA.<\/span><\/p>\n

Results: <\/strong>MVC torque decreased smaller and recovered faster (e.g., 4 days post-exercise: -31 \u00b1 13 % vs. -15 \u00b1 15 %), and peak serum CK activity was smaller (peak: 7684 \u00b1 8959 IU\/L vs. 3398 \u00b1 3562 IU\/L) for curcumin than placebo condition (P < 0.05). However, no significant differences between conditions were evident for other variables, and no significant changes in IL-6 and TNF-\u03b1 were evident after exercise.<\/span><\/p>\n

Conclusion: <\/strong>It is concluded that theracurmin ingestion attenuates some aspects of muscle damage such as MVC loss and CK activity increase.<\/span><\/p>\n

Authors:<\/strong>Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu Ra, Atsushi Imaizumi, Yoshihiko Otsuka, Kazunori Nosaka (Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan).<\/p>\n

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Nexala\u00ae 30 Capsules used for: People with joint problems related to age, proffessional activity or sports. Nexala\u00ae 30 Capsules: Oxidative stress is defined as an excess in the formation or an insufficient removal of highly reactive molecules that can cause oxidative damage. Curcumin, can help control oxidative stress.\u00a0The bioactive turmeric extract (Theracurmin\u00ae), included […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":""},"yoast_head":"\n